Clinical Trials Update

Clinical trials update 2015: Year in review.

This section of Headache annually reviews the status of recently completed and ongoing major clinical trials involving common headache disorders. The review will focus on multicenter trials of new therapies, as well as novel formulations of previously approved therapeutics. The Table summarizes the major therapeutic headache trials that were ongoing at the end of 2015, according to data obtaine...

Update on Clinical Trials for Malignant Melanoma

Evaluation of Clinical Trials

In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...

CLINICAL CARDIOLOGY: PHYSICIAN UPDATE Clinical Trials in Cardiovascular Medicine

The practice of cardiology is increasingly driven by evidence-based medicine centering around the results of clinical trials.1 In this inaugural article of Clinical Cardiology: Physician Update, I will focus on the design, analysis, and interpretation of clinical trials in cardiovascular medicine. Armed with the tools described herein, clinicians will be better equipped to understand and synthe...

Evidence Based Medicine: Clinical Trials

Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...